This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson’s Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children. From the contents: Preface.- ADHD Modeling by Perinatal Insult in Animals.- Perinatal Insults to Model Human Neuro-Psychiatric Disorders.- Selective Life-long Destructive of Brain Monoaminergic Nerves.- NGF in Perinatal Development.- Life-long Susceptibility Consequent to Perinatal Substances of Abuse.- Schizotypic Effects of Perinatal Insults. “This informative new book, written and edited by researchers in the field of the neuroteratology, presents the most recent data regarding how perinatal insults of various types can produce effects in the brain that persist throughout the lifespan. … The editors and chapter authors provide important information about toxic exposure during pregnancy. The target audience is ‘those engaged in studies in neuro- ontogeny; the book is also important collisions involved in the care of pregnant women or children.’” (Michael Joel Schrift, Doody’s Book Reviews, December, 2016)
This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson’s Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.
Highlights the major perinatal insults in animals that model human disorders
Describes actions and outcomes of notable neuroteratogens/neurotoxins that alter neuronal ontogeny
Provides a perspective towards experimental approaches in behavioral teratology
