Organic Transistor Devices for In Vitro Electrophysiological Applications

This thesis reports on a novel system for
extracellular recordings of the activity of excitable cells, which relies on an
organic, charge-modulated field-effect transistor (FET) called OCMFET. The
book shows how, thanks to the intrinsic biocompatibility, lightness, and
inexpensiveness of the material used, this new system is able to overcome several
problems typical of of “classic” electronic and
bioelectronic. It
provides a full description of the system, together with a comprehensive report
of the successful experimental trials carried out on both cardiac and nerve
cells, and a concise yet comprehensive overview of bioelectronic interfaces and
organic sensors for electrophysiological applications.

Introduction.- Bio-electronics Interfaces.- Organic Devices for Electrophysiological Applications.- The Micro Organic Charge Modulated FET Array.- Experimental Results.-Conclusions.

This thesis reports on the Micro OCMFET Array, a novel, reference-less

system for extracellular recordings of action potentials. The book 

provides readers with a full description of the system, together with an

extensive report of the successful experimental trials carried out on both

cardiac and nerve cells. Moreover, it offers a concise yet comprehensive

overview of both bioelectronic interfaces, such as Micro Electrode Arrays

(MEAs) and Field Effect Devices (FEDs), and organic sensors for electro-

physiological applications, including Organic Charge-Modulated FETs

(OCMFET), Electrolyte-Gated Organic FETs (EGOFETs), and Organic

Electrochemical Transistors (OECTs).

Nominated as an outstanding PhD thesis by the University of Genoa, Italy

Reports on the design and implementation of an innovative organic transistor device for in vivo and in vitro extracellular recordings