This text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options.
Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts.
1 The Alagille Syndrome: Overview and Introduction
David Piccoli
2 Bile Duct Development and the Notch Signaling Pathway
Stacey S. Huppert, Kathleen M. Campbell
3 Genetics of Alagille Syndrome
Melissa A. Gilbert, Nancy B. Spinner
4 Liver Disease in Alagille Syndrome
Alyssa Kriegermeier, Andrew Wehrman, Binita M. Kamath, Kathleen M. Loomes
5 Transplant Considerations in Alagille Syndrome
Evelyn Hsu, Elizabeth Rand
6 Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille Syndrome
Justin T. Tretter, Doff B. McElhinney
7 Vascular Manifestations in Alagille Syndrome
Shannon M. Vandriel, Rebecca N. Ichord, Binita M. Kamath
8 The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney Development
René Romero
9 Skeletal Involvement in Alagille Syndrome
Yadav Wagley, Troy Mitchell, Jason Ashley, Kathleen M. Loomes, Kurt Hankenson
10 Immune Dysregulation in Alagille Syndrome: A Feature of the Evolving Phenotype
Alastair Baker
11 Health-Related Quality of Life and Neurocognition in Alagille Syndrome
Saeed Mohammad, Estella M Alonso
12 Future Therapeutic Approaches for Alagille Syndrome
Emma R. Andersson
Binita M. Kamath, MBBChir MRCP MTR
The Hospital for Sick Children
Division of Gastroenterology, Hepatology and Nutrition
Toronto, ON
Canada
Kathleen M. Loomes, MD
Children’s Hospital of Philadelphia
Division of Gastroenterology, Hepatology and Nutrition
Department of Pediatrics
Philadelphia, PA
USA
This text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options.
Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts.
Provides a concise yet comprehensive overview of Alagille syndrome
Outlines management challenges, strategies, and future treatment options
Written by experts in the field
Provides a concise yet comprehensive overview of Alagille syndrome
Features management challenges and strategies, as well as future treatment options
Written by experts in the field
