This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the reader.
Written by experts in the field, Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist is a valuable resource on pediatric HSCT suited for pediatric hematologists-oncologists, fellows, advanced practitioners, clinical nurses, and other referring physicians.
Part I. Introduction, History and the Basic Principles of Pediatric Hematopoietic Stem Cell Transplantation (HSCT)
1. Introduction
Valerie I. Brown
2. Historical Overview of Pediatric HSCT
Valerie I. Brown
3. Brief Introduction to the Basic Scientific Principles of Hematopoietic Stem Cell Transplantation (HSCT)
Valerie I. Brown
Part II. Topics Related to the Pre- HSCT Period
4. Pretransplantation: Indications and Timing
Alicia McFarren and Michael A. Pulsipher
5. Spotlight on Minimal Residual Disease (MRD): Impact of MRD on HSCT Outcomes for Pediatric Leukemia
Abdel-Azim and Michael A. Pulsipher
6. HSCT Recipient Pretransplantation Evaluation
Carrie Eichelberger and Valerie I. Brown
7. How to Select a Donor and Hematopoietic Stem Cell Source: Related versus Unrelated Donors for Allogeneic HSCT
Malika Kapadia and Robert Greiner
8. Donor Evaluation, Selection and Hematopoietic Stem Cell Mobilization, Procurement and Manipulation
William Ferguson and Aleksander Babic
9. Preparing the Patient for HSCT: Conditioning Regimens and their Scientific Rationale
Carrie Kitko, Katie Gatwood, James Connelly
Part III. The Peri- HSCT Period: Pre-Engraftment (Days 0-30) and Early Post- HSCT (Days 30-100) Periods
10. Engraftment and Chimerism
Valerie I. Brown
11. Graft Failure
Valerie I. Brown
12. Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome
Mala K. Talekar and Jason L. Freedman
13. Nutrition in the Peri-HSCT Period
Arun Gurunathan, Judy Bailer, Jason L. Freedman
14. Mucositis and Pain in the Peri- HSCT Period
Arun Gurunathan, Neil S. Patel, Jason L. Freedman
15. Hepatoxicity in the Peri- HSCT Period
Valerie I. Brown
16. Renal Toxicities in the Peri-HSCT Period
Malika Kapadia, Terry Shapiro and Robert Greiner
17. Infectious Complications and HSCT
Karen Bride, Ellen Levy, Anne Wohlschlaeger, Jason L. Freedman
18. Acute Graft-Versus-Host Disease: Diagnosis, Prophylaxis, and Treatment
Karen L. Bride, Neil S. Patel, Jason L. Freedman
Part IV. The Late Post- HSCT Period (> 100 Days)
19. Chronic GVHD
Terry Wikle Shapiro, Malika Kapadia
20. Hematologic Complications Associated with HSCT
Mala K. Talekar and Timothy Olson
21. Pulmonary Complications Associated with HSCT
Malika Kapadia and Terry Shapiro
22. Renal Complications Associated with HSCT
Lena E. Winestone, Alix E. Seif, Benjamin L. Laskin
23. Cardiac Complications Associated with HSCT
Valerie I. Brown
24. Neurologic and Sensory Complications Associated with HSCT
Valerie I. Brown
25. HSCT-Associated Complications of the Skin, Hair and Nails
Valerie I. Brown
Part V: Life After HSCT
26. Immune Reconstitution after Hematopoietic Stem Cell Transplantation
Mala K. Talekar and Timothy Olsen
27. Life After HSCT: Survivorship and Long-Term Issues
Smita Dandekar
Part VI. Pharmacologic-Related Issues of Pediatric HSCT
28. Medications commonly Used in Pediatric HSCT
Kevin Mulieri, Ashley Teusink-Cross, JoEllen Wellnau, Krisoula Horiates, Katie S. Gatwood
Valerie I. Brown, MD, PhD
Director, Experimental Therapeutics, Pediatric Hematology/Oncology
Director, Pediatric Hematology/Oncology Fellowship Program
Penn State Milton S. Hershey Medical Center and Children’s Hospital, Division of Pediatric Oncology/Hematology, Hershey, PA, USA
This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the reader.
Written by experts in the field, Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist is a valuable resource on pediatric HSCT suited for pediatric hematologists-oncologists, fellows, advanced practitioners, clinical nurses, and other referring physicians.
Formatted to integrate the scientific basis of HSCT and ethical considerations into a relevant clinical framework
Features diagrams, illustrations, and tables that summarize key points and concepts for each chapter
Written by experts in the field
Formatted to integrate the scientific basis of HSCT and ethical considerations into a relevant clinical framework
Features diagrams, illustrations, and tables that summarize key points and concepts for each chapter
Written by experts in the field
