This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.
Table of Contents
High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management
Chrysalyne D. Schmults, editor
Dedication
Preface
Part I. Defining the Problem of High-risk SCC
- Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma
Pritesh S. Karia
- Tumor Staging Systems and Prognostic Stratification
Anokhi Jambusaria-Pahlajani
Part II. The Science of SCC
- Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-risk Cutaneous Squamous Cell Carcinoma
Catherine Anne Harwood, Charlotte Proby, Sarah Arron
- Molecular and Cellular Interplay in SCC Including Immunomodulation and Clinical Implications
Valerie Yanofsky, John A. Carucci, Günther F.L. Hofbauer
Part III. Management of High-risk SCC
- Management of Patients with Multiple SCCs/Field Cancerization
Sasha Jenkins Haberle, Lauren Rimoin, Myrto Georgia Trakatelli, Fiona Zwald
- Management of High-Risk Primary Tumors including Nodal Staging
Vishal Anil Patel, Christian L. Baum, Désirée Ratner
- Management of Local Recurrence and In-transit Metastasis
Vitaly Terushkin, John A. Carucci
- Management of Nodal Metastases
Michael Veness, Julie Howle
- Management of Widely Metastatic and Unresectable Cutaneous Squamous Cell Carcinoma
Glenn J. Hanna, Emily Stamell Ruiz, Jochen H. Lorch
- Immune Dysfunction and Immunosuppression: Impacts on SCC Incidence, Prognosis, and Management
Travis W. Blalock, Thomas Stasko
“This book explores the immune and epigenetic mechanisms responsible for the development of squamous cell carcinoma. … The audience is dermatologists and oncologists. … When faced with a patient with a high-risk squamous cell carcinoma, this is the reference to turn to for the most up-to-date, multidisciplinary approach.” (Patricia Wong, Doody’s Book Reviews, August, 2016)
Chrysalyne Schmults, MD, MSCE
Director, Mohs & Dermatologic Surgery Center
Brigham & Women’s Hospital
Department of Dermatology
1153 Centre St., Suite 4349
Jamaica Plain, MA 02130, USA
Only text devoted to squamous cell carcinoma of the skin with a focus on high-risk tumors that may recur or metastasize
Summaries of new prognostic information and staging systems allowing more precise definition of high-risk tumors
Tips on practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease
