This comprehensive work broadens readers’ understanding of the rudimentary mechanism of the anti-cancer effect of hyperthermia. It also presents state-of-the-art clinical outcomes by hyperthermia treatment of cancer.
In the past few decades, basic and clinical research have shown through in vitro experiments that hyperthermia inhibits epithelial-mesenchymal transition (EMT), resulting in the prevention of metastasis. It also has been learned that hyperthermia shows its superior benefit when applied in combination with radiation therapy, chemotherapy, or various immunotherapies as treatments of several types of carcinoma. The chapters here from expert contributors describe the details of their research for each type of cancer.
This book provides not only an overview and the current status of hyperthermia but also its future perspectives. Therefore this volume will greatly benefit oncologists, radiologists and radiology technologists, and chemotherapists who are involved in immunotherapy for all kinds of cancer.
Part I. Basic Science in Cultured Cells.- 1. Introduction.- 2.Induction of oxidative stress by hyperthermia and enhancement of hyperthermia-induced apoptosis by oxidative stress modification.- 3.Molecular Damage: Hyperthermia Alone.- 4.Roles of HSF1 and Heat Shock Proteins in Cancer.- 5.Cellular Responses in Signal Transduction Pathways Induced by Hyperthermia.- 6.Cell cycle responses to hyperthermia.- 7.Thermo-tolerance.- 8.Enhancement of Hyperthermia on Radio-sensitivity.- 9.Inhibition of DNA repair system activity.- 10. Enhancement of Hyperthermia on Anti-tumor Drug Sensitivity.- 11. Inhibition of epithelial-to-mesenchymal transition (EMT) by hyperthermia.- Part II. Basic Science in Whole Body.- 12.Potentiating Immune System by Hyperthermia.- 13. Magnetic Nanoparticle-Mediated Hyperthermia and Induction of Anti-Tumor Immune Responses.- 14. Tumor Microenvironment and Hyperthermia Part III. Clinical Science in Cancer Patients..- 15. Hyperthermia Alone.- 16.Combination by Hyperthermia and Radiation (and Chemotherapy): Oral and Maxillofacial Cancer.- 17.Combination by Hyperthermia and Radiation (and Chemotherapy): Lung Cancer.- 18.Efficacy of hyperthermia in combination with radiation therapy for breast cancer.- 19.Combination by Hyperthermia and Radiation: Esophageal Cancer.- 20.Combination by Hyperthermia and Radiation (and Chemotherapy): Gynecology Cancer.- 21.Combination by Hyperthermia and Radiation and Chemotherapy: Soft Tissue Sarcoma.- 22.Combination by Hyperthermia and Chemotherapy: Lung Cancer.- 23. Combination by Hyperthermia and Chemotherapy: Breast Cancer.- 24.Combination by Hyperthermia and Chemotherapy: Esophageal Cancer.- 25.Combination by Hyperthermia and Chemotherapy: Liver Cancer.- 26.Hyperthermia Combined with Chemotherapy: Pancreatic Cancer.- 27.Effect of hyperthermia in combination with chemotherapy and radiation therapy for treatment of urological cancer (prostate cancer and urothelial cancer).- 28.Combination by Hyperthermia and Surgery.- 29.Combining Hyperthermia and Immunotherapy: NK Therapy and Hyperthermia.- 30.Combination by Hyperthermia and Immunotherapy: DC Therapy and Hyperthermia.- 31.Effects of fever-range hyperthermia on T cell-mediated immunity: possible combination of hyperthermia and T cell-based cancer immunotherapy.- 32.Combination of Hyperthermia and Immunotherapy: Hyperthermia and Naive T-cell Therapy.- 33.HIPEC for Peritoneal Dissemination.- 34.A new comprehensive treatment for peritoneal metastases using cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion.- 35.Non-invasive Temperature Moniterring.- 36.Development of Heating Device.- 37. Epilogue.
Dr. Satoshi Kokura
KOKURA Lab, Health and Medical
Sciences, Kyoto Gakuen University
Dr. Toshikazu Yoshikawa
Kyoto Prefectural University of
Dr. Takeo Ohnishi
Department of Radiation Oncology
Nara Medical University
Broadens understanding of the rudimentary mechanism of the anti-cancer effect of hyperthermia
Provides the latest clinical outcomes by hyperthermia treatment of cancer
Presents the future perspectives for hyperthermia treatment