This book introduces the latest advances relating to the pathophysiology, biophysics, monitoring and treatment of traumatic brain injury, hydrocephalus, and stroke presented at the 16th International Conference on Intracranial Pressure and Neuromonitoring (the “ICP Conference”), held in Cambridge, Massachusetts, in June 2016 in conjunction with the 6th Annual Meeting of the Cerebral Autoregulation Research Network. Additionally, the conference held special sessions on neurocritical care informatics and cerebrovascular autoregulation. The peer-reviewed papers included were written by leading experts in neurosurgery, neurointensive care, anesthesiology, physiology, clinical engineering, clinical informatics and mathematics who have made important contributions in this translational area of research, and their focus ranges from the latest research findings and developments to clinical trials and experimental studies. The book continues the proud tradition of publishing key work from the ICP Conferences and is a must-read for anyone wishing to stay abreast of recent advances in the field.
Part 1 Traumatic Brain Injury.- Cerebral perfusion pressure variability between patients and between centers.- Pre-hospital predictors of impaired ICP trends in continuous monitoring of paediatric traumatic brain injury patients.- Prognosis and outcomes of severe traumatic brain injury in children.- Do ICP – derived parameters help to differentiate Vegetative State (VS) from other outcome groups after traumatic brain injury?.- The Cerebral Arterial Compliance in Severe Head Injury.- The Сerebrovascular Resistance in Severe Polytraumazed Patients with Intracranial Hematomas.- Computed tomography indicators of deranged ICP-derived indices in paediatric traumatic brain injury.- Mean square deviation of ICP in prognosis of outcomes in severe TBI of children.- KidsBrainIT – A new Multi-centre, multi-disciplinary, and multi-national Paediatric Brain Monitoring Collaboration.- Cerebral haemodynamics during experimental increases in ICP.- What determines outcome in patients that suffer raised intracranial pressure after traumatic brain injury?.- Visualisation of the ‘Optimal Cerebral Perfusion’ landscape in severe traumatic brain injury patients.- Is there a relationship between optimal cerebral perfusion pressure guided management and PaO2/FiO2 ratio after severe traumatic brain injury?.- Part 2 Brain Monitoring Technology.- Non invasive intracranial pressure in brain injured patients: a comparison between three methods based on Duplex Color.- ANALYSIS OF A NONINVASIVE INTRACRANIAL PRESSURE MONITORING METHOD IN PATIENTS WITH TRAUMATIC BRAIN INJURY.- Comparison of different calibration methods in a non-invasive ICP assessment model.- An Embedded Device for Real-Time Noninvasive ICP Estimation.- Transcranial Bioimpedance Measurement as a Non-Invasive Estimate of Intracranial Pressure.- Pulsed electromagnetic field .- Volumetric Ophthalmic Ultrasound for Inflight Monitoring of Visual Impairment and Intracranial Pressure.- Does the variability of evoked TMD data (Vm) increase as the magnitude of the pulse amplitude increases?.- ANALYSIS OF MINIMALLY INVASIVE INTRACRANIAL PRESSURE SIGNALS DURING INFUSION IN THE SUBARACHNOID SPINAL SPACE OF PIGS.- A Wearable Transcranial Doppler Ultrasound Phased Array System.- Comparison of macro- and microcirculatory cerebral blood flow in healthy controls using contrast-enhanced ultrasound.- HDF5 based data format for archiving complex neuro-monitoring data in Traumatic Brain Injury patients.- Part 3 Neurocritical Care Informatics.- Influence of general anaesthesia on slow vasogenic waves of intracranial pressure.- Critical closing pressure during controlled increase in intracranial pressure.- Effect of mild hypocapnia on critical closing pressure and other mechanoelstic parameters of cerebrospinal system.- Occurrence of CPPopt values in uncorrelated ICP an ABP time series.- Simultaneous transients of ICP and heart rate.- Increasing the Contrast-to-Noise Ratio of MRI Signals for the Regional Assessment of Dynamic Cerebral Autoregulation.- Linear and nonlinear SVM finite imputes response.- ICP and antihypertensive drugs.- ICP: From correlation to causation.- A waveform archiving agent for the GE Solar.- Deriving PRx and CPPopt from 0.2 Hz data: Establishing Generalizability to Bedmaster Users.- MFER Representation of Neurointensive Care Waveform Data.- Multi-Scale Peak and Trough Detection Optimised for Periodic and Quasi-Periodic Neuroscience Data.- Room air readings of brain oxygen probes.- What do we mean by cerebral perfusion pressure?.- Investigation of the relationship between the burden of raised ICP and the length of stay in a neuro-intensive care unit.- Optimal cerebral perfusion pressure in a prospective traumatic brain injury cohort.- Part 4 Hydrocephalus and CSF Biophysics.- Visual Impairment Intracranial Pressure Syndrome-Related Globe Deformations in Astronauts are linked to CSF Volume Increase.- MRI criteria for diagnosis of communicating chronic hydrocephalus in adults.- Is there a link between ICP-derived infusion test parameters and outcome after shunting in NPH ?.- Mathematical modelling of CSF stroke volume in aqueduct cerebri.- CSF and cerebral blood flows in idiopathic intracranial hypertension.- Significant Association of Slow Vasogenic ICP Waves with Normal Pressure Hydrocephalus Diagnosis.- ICP monitoring and Phase contrast MRI to investigate intracranial compliance.- Numerical Cerebrospinal System Modeling in Fluid-Structure Interaction.- Part 5 Cerebrovascular Autoregulation.- Differential systolic and diastolic regulation of the cerebral pressure-flow relationship during squat-stand manoeuvres.- Normative Ranges of Transcranial Doppler Metrics.- Autoregulation enhances collateral flow through the circle of Willis.- Simultaneous assessment of intracranial pressure and pressure reactivity index by ventricular catheter and ICP probe.- Comparison of intracranial pressure and pressure reactivity index obtained through pressure measurements in the ventricle and in the parenchyma during and outside cerebrospinal fluid drainage episodes in a manipulation free patient setting.- Visualizing autoregulation insults and their association with outcome in adult traumatic brain injury.- RAP as an Index of Cerebral Hemodynamic Stability after Brain Injury.- Systolic and diastolic regulation of the cerebral pressure-flow relationship differentially affected by acute sport-related concussion.- Induced Dynamic Intracranial Pressure (ICP) Reactivity (iPRx) and Cerebrovascular Reactivity (iCVRx) Assessment of Cerebrovascular Autoregulation after Traumatic Brain Injury (TBI) with High Intracranial Pressure (ICP) in Rats.- Prediction of the time to syncope occurrence in patients diagnosed with vasovagal syncope.- Statistical signal properties of the pressure-reactivity index (PRx)
“This book will be of most interest to bioengineers interested in cerebrovascular autoregulation, CSF biophysics, and physiological monitoring of the brain. It also will be of some interest to academic neurotraumatologists and neurointensivists. … The editor has provided an index of key words at the end of the book, referred to as a ‘subject index’ that will efficiently take the reader directly to the studies of interest to them.” (DonaldW. Marion, Neurosurgery, Vol. 84 (4), April, 2019)
Thomas Heldt is the W.M. Keck Career Development Professor in Biomedical Engineering at MIT’s Institute for Medical Engineering & Science. He is also an Associate Professor of Electrical and Biomedical Engineering in MIT’s Department of Electrical Engineering & Computer Science and a Principal Investigator with MIT’s Research Laboratory of Electronics where he directs the Integrative Neuromonitoring and Critical Care Informatics Group.
Dr. Heldt studied Physics at Johannes Gutenberg University, Germany, at Yale University, and MIT. In 2004, he received the PhD degree in Medical Physics from MIT’s Division of Health Sciences and Technology and commenced postdoctoral training at MIT’s Laboratory for Electromagnetic and Electronics Systems.
Dr. Heldt’s research interests focus on signal processing, mathematical modeling, and model identification to support real-time clinical decision making, monitoring of disease
progression, and titration of therapy, primarily in neurocritical and neonatal critical care. In particular, Dr. Heldt is interested in developing a mechanistic understanding of physiologic systems, and in formulating appropriately chosen computational physiologic models for improved patient care. His research is conducted in close collaboration with colleagues at MIT and clinicians from Boston-area hospitals.
This book introduces the latest advances relating to the pathophysiology, biophysics, monitoring and treatment of traumatic brain injury, hydrocephalus, and stroke presented at the 16th International Conference on Intracranial Pressure and Neuromonitoring (the “ICP Conference”), held in Cambridge, Massachusetts, in June 2016 in conjunction with the 6th Annual Meeting of the Cerebral Autoregulation Research Network. Additionally, the conference held special sessions on neurocritical care informatics and cerebrovascular autoregulation. The peer-reviewed papers included were written by leading experts in neurosurgery, neurointensive care, anesthesiology, physiology, clinical engineering, clinical informatics and mathematics who have made important contributions in this translational area of research, and their focus ranges from the latest research findings and developments to clinical trials and experimental studies. The book continues the proud tradition of publishing key work from the ICP Conferences and is a must-read for anyone wishing to stay abreast of recent advances in the field.
Focuses on neurocritical care monitoring and cerebrovascular autoregulation
Includes intracranial pressure biophysics
Presents the latest research findings and developments in clinical trials and experimental studies
