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Metastatic Bone Disease

An Integrated Approach to Patient Care

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EAN: N/A SKU: 9781493979332 Categories: , , , , ,

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Weight 988 g
Dimensions 178 × 254 mm
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About The Author

Randall, R. Lor

Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and bio targeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike.

The book provides an essential reference on metastatic bone disease (MBD) for practicing orthopedists. It features rich and detailed images for diagnostic and referential purposes and includes the insights of leading practitioners and researchers.

Part One         The Problem

Chapter 1        Bone Metastases: Epidemiology and Societal Effect

                        Robert U. Ashford and R. Lor Randall

 

Part Two        Biology of Metastases and Tissue of Origin Considerations

Chapter 2        Pathobiology of Osteolytic and Osteoblastic Bone Metastases

                        Antonella Chiechi and Theresa A. Guise

Chapter 3        Biology of Bone Cancer Pain

                        Patrick W. O’Donnell and Denis R. Clohisy

Chapter 4        Breast Cancer Bone Metastases

                        Sarah Colonna and Theresa L. Werner

Chapter 5        Prostate Cancer Bone Metastasis

                        Jonathan D. Tward

Chapter 6        Lung

                        Shamus R. Carr

Chapter 7        Kidney Metastatic Bone Disease

                        Patrik Luzny and Christopher Dechet

Chapter 8        Thyroid

                        Elie Klam and Dev Abraham

Chapter 9        Myeloma

                        Srinivas K. Tantravahi and Tibor Kovacsovics

 

Part Three     Work-Up for Patients with Suspected Metastatic Bone Disease

Chapter 10      Evaluation of the Patient with Carcinoma of Unknown Origin Metastatic to Bone

                        Bruce T. Rougraff and Terence J. Cudahy

Chapter 11      Biopsy Considerations

                        Daniel M. Lerman

 

Part Four       Medical Therapy

Chapter 12      Bisphosphonates, Denosumab and Anabolic Agents in the Treatment of                                         Metastatic Bone Disease

                        Z. Deniz Olgun, Arianna Gianakos, Jonathan E. Jo, Joseph M. Lane

Chapter 13      Biotargeting in Metastatic Bone Disease

                        Anna R. Cooper, Wakenda Tyler, and Emily E. Carmody

 

Part Five        Supportive Oncology

Chapter 14      Psychosocial Considerations for Patients with Metastatic Bone Disease

                        Amy Horyna

Chapter 15      Pain Management in Metastatic Bone Disease

                        Shane E. Brogan and Daniel W. Odell

Chapter 16      When is Hospice Appropriate?  The Role for Hospice in Palliating Patients with                             Bone Metastases

                        Andrew Badke and Anna C. Beck

 

Part Six          Radiation Oncology

Chapter 17      Current and Emerging Modalities

                        Hilary P. Bagshaw and Jonathan D. Tward

 

Part Seven      Interventional Oncology

Chapter 18      Ablation and Cementation Technologies

                        Aaron E. Frodsham and Laura B. Eisenmenger

 

Part Eight      Principles of Orthopaedic Surgical Oncology

Chapter 19      Issues Facing the Established Metastatic Bone Disease Patient,                                                       Timing/Indications for Surgery

                        George T. Calvert

Chapter 20      Questions to Ask Your Medical Oncology Colleagues

                        Noah Federman, Amanda Loftin, and Nicholas M. Bernthal

Chapter 21      Consideration of the Temporal Relationship between Surgery and Radiation                                  Therapy

                        Daniel M. Lerman

Chapter 22      Role of Surgery in Oligometastatic Disease

                        George T. Calvert

 

Part Nine        Specific Anatomic Considerations for Surgery

Chapter 23      Metastatic Bone Disease: Pelvis

                        Vishal Hegde and Nicholas M. Bernthal

Chapter 24       Metastatic Bone Disease: Femur

                        Shawn L. Price

Chapter 25      Metastatic Bone Disease: Femur: Tibia

                        Nicholas P. Webber

Chapter 26      Metastatic Bone Disease: Foot

                        Judd E. Cummings

Chapter 27      Metastatic Bone Disease: Femur: Humerus, Scapula

                        Michael J. Monument and Shannon K.T. Puloski

Chapter 28      Metastatic Bone Disease: Forearm, Hand

                        Russell Ward

Chapter 29      Metastatic Bone Disease: Spine

                        Matthew W. Colman and William Ryan Spiker

 

Part Ten         Emerging Surgical Technologies

Chapter 30      Intraoperative Imaging and Navigation

                        John A. Abraham and Christina J. Gutowski

 

Part Eleven    Putting it All Together

Chapter 31      Integrative Approach with the Patient in Mind: A Glance Forward

                        R. Lor Randall

R. Lor Randall, MD, FACS, The L.B. & Olive S. Young Endowed Chair for Cancer Research Director, Sarcoma Services & Medical Director, HCI Surgical Services Chief, SARC Lab & Fellowships Co-Leader, Sarcoma Disease Oriented Research Team, Professor of Orthopaedics, Primary Children’s Hospital & Huntsman Cancer Institute, The University of Utah Salt Lake City, UT.

Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and biotargeting. The heart of the book presents oncological approaches (supportive, radiation, and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike.

Covers all aspects of surgical and medical intervention in metastatic bone disease for orthopedic surgeons and oncologists

Presents mechanistic biology, work-up, medical therapy, radiation and interventional oncology, principles and techniques of orthopedic surgical oncology and emerging technologies

Features rich and detailed images for diagnostic and referential purposes