The book
presents a new, powerful model of neuronal networks, consisting of a
three-dimensional neuronal culture in which 3D neuronal networks are coupled to
micro-electrode-arrays (MEAs). It discusses the main advantages of the
three-dimensional system compared to its two-dimensional counterpart, and shows
that the network dynamics, recorded during both spontaneous and stimulated
activity, differs between the two models, with the 3D system being better able
to emulate the in vivo behaviour of neural networks. The book offers an
extensive analysis of the system, from the theoretical background, to its
design and applications in neuro-pharmacological studies. Moreover, it
includes a concise yet comprehensive introduction to both 2D and 3D neuronal
networks coupled to MEAs, and discusses the advantages, limitations and
challenges of their applications as cellular and tissue-like in vitro experimental model systems.
Introduction.- Dissociated Neuronal Networks Coupled to
Micro-Electrode Arrays Devices.- In Vitro Neuronal Networks.- 3D Neuronal
Networks: State of the Art.- 3D Neuronal Networks Coupled to MEAs.- Neuro-pharmacological
Studies.- Discussion and Conclusion.- Data Analysis.
The book
presents a new, powerful model of neuronal networks, consisting of a
three-dimensional neuronal culture in which 3D neuronal networks are coupled to
micro-electrode-arrays (MEAs). It discusses the main advantages of the
three-dimensional system compared to its two-dimensional counterpart, and shows
that the network dynamics, recorded during both spontaneous and stimulated
activity, differs between the two models, with the 3D system being better able
to emulate the in vivo behaviour of neural networks. The book offers an
extensive analysis of the system, from the theoretical background, to its
design and applications in neuro-pharmacological studies. Moreover, it
includes a concise yet comprehensive introduction to both 2D and 3D neuronal
networks coupled to MEAs, and discusses the advantages, limitations and
challenges of their applications as cellular and tissue-like in vitro experimental model systems.
<
Nominated as an outstanding PhD thesis by the University of Genoa, Italy
Presents a powerful in vitro model of neuronal network dynamics
Reports on the
implementation of bio-hybrid microsystems for network electrophysiology
