This book provides a current understanding of Continuous Renal Replacement Therapies (CRRT) techniques with a focus on drug dosing in critically ill children receiving CRRT. Strategies include the role of therapeutic drug monitoring, effect of CRRT on drug pharmacokinetics, variations in the drugs properties, newer kidney injury biomarkers and simple and easy methods for estimating drug clearance. The conclusion of this book features case reports focused on the patients’ symptoms and laboratory data as they present in clinical practice and the type of CRRT modality needed to provide quality, safety, and cost-effectiveness of patient care. Pediatric Continuous Renal Replacement Therapy will expand the clinical knowledge and experience of practicing nephrologists and other professionals involved in the care of children suffering from Acute Kidney Injury (AKI) to improve and sustain their quality of life.
Acute kidney injury
CRRT as treatment
Water and solute movements: basic physiology
CRRT modalities
Hemodialysis (diffusive) versus hemofiltraion (Convective) CVVH
CRRT Principles
General consideration for CRRT
Specific consideration for pediatric CRRT
Vascular access and catheter size
Blood flow rate (BFR)
Ultrafiltation rates
Calculating the desired fluid removal rate
Replacement/dialysate solutions
Drug dosing in CRRT
Blood priming
Nutrition in CRRT
Monitoring during CRRT
Compliance of CRRT
Replacement/dialysate solution composition
Factors influencing the clearance of drug during CRRT
CRRT impact on pharmacokinetic parameters
Case Studies
“The book is written for residents and practitioners in pediatric critical care and nephrology. … It covers acute kidney injury, pharmacology of drugs in acute kidney injury, and continuous renal replacement therapy modalities.” (Aftab Chishti, Doody’s Book Reviews, September, 2017)
Farahnak Assadi, M.D.
Distinguished Professor, Emeritus
Department of Pediatrics
Rush University Medical College
Division of Nephrology
Rush Children’s Hospital
Chicago, Illinois
USA
Fatemeh Ghane Sharbaf, M.D.
Associate Professor
Department of Pediatrics
Section of Nephrology
Mashhad University of Medical Sciences
Mashhad, Iran
This book provides a current understanding of Continuous Renal Replacement Therapies (CRRT) techniques with a focus on drug dosing in critically ill children receiving CRRT. Strategies include the role of therapeutic drug monitoring, effect of CRRT on drug pharmacokinetics, variations in the drugs properties, newer kidney injury biomarkers and simple and easy methods for estimating drug clearance. The conclusion of this book features case reports focused on the patients’ symptoms and laboratory data as they present in clinical practice and the type of CRRT modality needed to provide quality, safety, and cost-effectiveness of patient care. Pediatric Continuous Renal Replacement Therapy will expand the clinical knowledge and experience of practicing nephrologists and other professionals involved in the care of children suffering from Acute Kidney Injury (AKI) to improve and sustain their quality of life.
Provides drug dosing strategies in pediatric patients with Acute Kidney Injury (AKI) and the latest clinical guidelines and understanding of Continuous Renal Replacement Therapy (CRRT)
Features case reports focused on the patients’ symptoms and laboratory data as they present in clinical practice and the type of CRRT modality needed to provide quality, safety, and cost-effectiveness of patient care
Designed to expand the clinical knowledge and experience of nephrologists and professionals from different specialties involved in the care of children suffering from AKI
