This fully-updated book provides systems-based methodologies and innovative technologies that can be used for solving complicated problems of complex systems. A wide range of theoretical and experimental approaches are introduced for practical applications, as the content explores the basic and novel concepts in psychoneuroimmunology (PNI), especially the relationships among stress, inflammation, and psychophysiological disorders, as well as various cutting-edge technologies and methods for PNI studies, including the utilizations of mouse models and vaccine models. In addition, this book focuses on translational medicine by applying PNI methods in clinical practice. As part of the Methods in Molecular Biology series, the chapters seek to provide a practical, state-of-the-art, and holistic view for the translation of PNI into better preventive and personalized medical practice.
Part I: Stress and Immunity: Biopsychosocial Models and Clinical Implications
1. Stress and Systemic Inflammation: Yin-Yang Dynamics in Health and Diseases
Qing Yan
2. Intersections between Neuroimmune-Microbiota
Colette G. Ngo Ndjom, Xavier F. Gonzalez, and Harlan P. Jones
3. Psychoneuroimmunology: The Experiential Dimension
Elling Ulvestad
4. Ecological Context and Human Variation: Applying the Principles of Biological Anthropology to Psychoneuroimmunology
Eric C. Shattuck
5. Neuroimmune Imbalances and Yin-Yang Dynamics in Stress, Anxiety, and Depression
Qing Yan
6. Increasing Resilience to Traumatic Stress: Understanding the Protective Role of Well-Being
J. Tory Toole, Mark A. Rice, Jr., Jordan Cargill, Travis J.A. Craddock, Barry Nierenberg, Nancy G. Klimas, Mary Ann Fletcher, Mariana Morris, Joel Zysman, and Gordon Broderick
7. Exploring the Diagnostic Potential of Immune Biomarker Co-Expression in Gulf War Illness
Gordon Broderick, Mary Ann Fletcher, Michael Gallagher, Zachary Barnes, Suzanne D. Vernon, and Nancy Klimas
8. Breaking Away: The Role of Homeostatic Drive in Perpetuating Depression
J. Tory Toole, Mark A. Rice, Jr., Travis J.A. Craddock, Barry Nierenberg, Nancy G. Klimas, Mary Ann Fletcher, Joel Zysman, Mariana Morris, and Gordon Broderick
9. Neuroimmune Mechanisms of Depression in Adults with Heart Failure
Jessica A. Jiménez, Christine Tara Peterson, and Paul J. Mills
10. How To Monitor the Neuroimmune Biological Response in Patients Affected by Immune Alteration-Related Systemic Diseases
Paolo Lissoni, Franco Rovelli, Luigi Vigorè, Giusy Messina, Arianna Lissoni, Giorgio Porro, and Giuseppe Di Fede
Part II: Technologies and Methods in Psychoneuroimmunology Studies
11. Application of Chemogenetics and Optogenetics to Dissect Brain-Immune Interactions
Ben Korin and Asya Rolls
12. Psychoneuroimmunology and Natural Killer Cells: The Chromium Release Whole Blood Assay
Mary Ann Fletcher, Zachary Barnes, Gordon Broderick, and Nancy G. Klimas
13. Mouse Testing Methods in Psychoneuroimmunology 2.0: Measuring Behavioral Responses
Albert E. Towers, Jason M. York, Tracy Baynard, Stephen J. Gainey, and Gregory G. Freund
14. The MRL Model: A Valuable Tool in Studies of Autoimmunity-Brain Interactions
Boris Šakić
15. PET Imaging in Psychoneuroimmunology Research
Jonas Hannestad
16. The Vaccination Model in Psychoneuroimmunology Research: A Review
Anna C. Whittaker
17. Measuring Vaccine Responses in the Multiplex Era
Kieran Ayling, Kavita Vedhara, and Lucy Fairclough
18. Sculpting the Sculptors: Methods for Studying the Fetal Cholinergic Signaling on Systems and Cellular Scales
Martin G. Frasch, Patrick Burns, Javier Benito, Marina Cortes, Mingju Cao, Gilles Fecteau, and André Desrochers
19. Perinatal Psychoneuroimmunology: Protocols for the Study of Prenatal Stress and Its Effects on Fetal and Postnatal Brain Development
Martin G. Frasch, Carlos J. Baier, Marta C. Antonelli, and Gerlinde A.S. Metz
This fully-updated book provides systems-based methodologies and innovative technologies that can be used for solving complicated problems of complex systems. A wide range of theoretical and experimental approaches are introduced for practical applications, as the content explores the basic and novel concepts in psychoneuroimmunology (PNI), especially the relationships among stress, inflammation, and psychophysiological disorders, as well as various cutting-edge technologies and methods for PNI studies, including the utilizations of mouse models and vaccine models. In addition, this book focuses on translational medicine by applying PNI methods in clinical practice. As part of the Methods in Molecular Biology series, the chapters seek to provide a practical, state-of-the-art, and holistic view for the translation of PNI into better preventive and personalized medical practice.
Includes cutting-edge and practical insight into the study of psychoneuroimmunology
