This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.
The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
Chapter 1
Cancer Epidemiology: Incidence and Etiology of Human Neoplasms
William B. Coleman and Gregory J. Tsongalis
Chapter 2
Essential Concepts and Techniques in Molecular Biology
Claudine L. Lefferts, PhD and Joel A. Lefferts, PhD
Chapter 3
Cancer Genomics
Jonathan R. Pollack
Chapter 4
Cancer Cytogenetics
Thomas Ried, Kerstin Heselmeyer-Haddad, Jordi Camps, and Timo Gaiser
Chapter 5
The Epigenetic Basis of Human Cancer
Thomas Mikeska and Alexander Dobrovic
Chapter 6
Cancer Proteomics
Jeffrey M. Lake and Timothy D. Veenstra
Chapter 7
An Overview of Cancer Genes
Ashley G. Rivenbark, PhD
Chapter 8
Oncogenes and the Initiation and Maintenance of Tumorigenesis
Dean W. Felsher, Constadina Arvanitis, Pavan Bendapudi, and Pavan Bachireddy
Chapter 9
Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors
Luca Grumolato, Ph.D. and Stuart Aaronson, M.D.
Chapter 10
Senescence, Apoptosis, and Cancer
Manjari Dimri and Goberdhan P. Dimri
Chapter 11
Novel Cancer Therapies Targeting Angiogenesis
Monte Willis and Nancy Klauber-DeMore
Chapter 12
Beyond the Primary Tumor: Progression, Invasion, and Metastasis
Danny R. Welch, Ph.D. and Douglas R. Hurst, Ph.D.
Chapter 13
Simple Sequence Mutations
Christophe Béroud and Mireille Claustres
Chapter 14
Single Nucleotide Polymorphisms and Cancer Susceptibility
Richard A. Hubner and Richard S. Houlston
Chapter 16Chromosomes and Chromosomal Instability in Human Cancer
Kazuma Ohyashiki, Masahiko Kuroda, and Junko H. Ohyashiki
Chapter 17
Epigenetic Mechanisms in Cancer Development
José Ignacio Martín-Subero and Manel Esteller
Chapter 18
MicroRNAs and Cancer
Phong Trang, Joanne Weidhaas, and Frank J. Slack
Chapter 19
Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas
Mutlay Sayan and Brooke T. Mossman
Chapter 20
Viral Mechanisms in Human Carcinogenesis
Paul F. Lambert, PhD
Chapter 21
Hormonal Carcinogenesis: The Role of Estrogens
William A. Ricke, Karin Williams, Jalissa Wynder, Ganesh Palapattu, Yuzhuo Wang, Gerald R. Cunha
Chapter 22
Sporadic Cancers
Clemens B. Tempfer and Marc-André Reymond
<
Chapter 23
Hereditary Cancer
Zoran Gatalica, MD, DSc, Anatole Ghazalpour, PhD Stan L. Lilleberg, PhD, Jeffrey Swensen, PhD, and Henry T. Lynch, MD
Chapter 24
Retinoblastoma: Clinical and Molecular Perspectives
Justis P. Ehlers MD and J. William Harbour MD
Chapter 25
Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light
James E. Cleaver
Chapter 26
Hereditary Colorectal Cancer
Sonia S. Kupfer and Nathan A. Ellis
Chapter 27
Lungs
<hereditary breast="" and="" ovarian="" cancer
Michael P. Lux, Mayada R. Bani, Peter A. Fasching, and Matthias W. Beckmann
Chapter 28
The Molecular Basis of Prostate Carcinogenesis
Smitha Dutt and Allen C. Gao
Chapter 29
Molecular Basis of Lung Carcinogenesis
Kwun M. Fong, Jill E. Larsen, Casey Wright, Krishna Sriram, Morgan Davidson, Marissa Daniels, Yoshitaka Sekido, Rayleen V. Bowman, Ian A. Yang, and John D. Minna
Chapter 30
The Molecular Basis of Skin Carcinogenesis
Alessia Pacifico, MD, Giovanni Leone, MD, Honnavara N. Ananthaswamy, PhD
Chapter 31
The Molecular Biology of Leukemias
L. Jeffrey Medeiros and Sergej N. Konoplev
Chapter 32
Molecular Mechanisms in Non-Hodgkin Lymphoma
John Hunt, MD, Yuri Fedoriw, MD and William N. Rezuke, Jr., MD
Chapter 33
The Molecular Pathology of Head and Neck Squamous Cell Carcinoma
Laura J. Tafe
Chapter 34
Ovarian Cancer
Amy D. Brockmeyer and Louis Dubeau, MD, PhD
Chapter 35
Molecular Pathology of Bone and Soft Tissue Tumors
José Luis Ordóñez PhD, Daniel Osuna PhD, Juan Madoz-Gúrpide PhD, Enrique de Álava, MD, PhD
Chapter 36
The Molecular Biology of Human Brain Tumors
Daniel Coluccia, Adrienne Weeks, Javier Fandino, Christian Schneider, Christian Smith, and James T. Rutka
Chapter 37
Cancer Drug Discovery and Anticancer Drug Development
James Turkson, PhD
Chapter 38
Heart
<biological principles="" and="" clinical="" application="" of="" egfr="" inhibitors="" in="" cancer
Zhuo (Georgia) Chen, PhD, Suresh Ramalingam, MD, and Dong M. Shin, MD
Chapter 39
Targeting Oncoproteins for Molecular Cancer Therapy
Joshua E. Allen and Wafik S. El-Deiry
Chapter 40
Therapeutic Agents that Inhibit Angiogenesis
Francesco Torino, Roberta Sarmiento, Raffaelle Longo, and Giampietro Gasparini
Chapter 41
Small Molecule Inhibitors
Xin Chen, Ph.D. and Jian Jin, Ph.D
Chapter 42
Molecular Detection and Diagnosis of Cancer
Christos Patriotis, Padma Maruvada, and Sudhir Srivastava
Chapter 43
Gene Therapy in the Treatment of Human Cancer
Anand C. Annan, MBBS, Paul B. Fisher, MPh, PhD, Paul Dent, PhD, Gene P. Siegal, MD, PhD, David T. Curiel, MD, PhD
Chapter 44
Personalized Medicine for the Treatment of Human Cancer
Scott A. Turner, PhD and Gregory J. Tsongalis, PhD
William B. Coleman
Department of Pathology and Laboratory medicine, Curriculum in
Toxicology, Program in Translational Medicine, UNC Lineberger
Comprehensive Center, University of North Carolina School of Medicine,
Chapel Hill, NC
This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.
The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
Written by experts in the field
Updated and revised to include current research
Richly illustrated
