This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text.
Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.
Section I: Introduction
History and Evolution of PDX Cancer Models
Section II: Establishment and Characterization of PDX Models
Methods of Generating PDX Models
Fidelity and Stability of PDX Models
Section III: Applications of PDX Models
Studies of Cancer Heterogeneity
PDX and Cancer Stem Cells
Modeling Cancer Metastasis
Modeling Drug Resistance
PDX and Biomarker Development
PDX and Preclinical Drug Screening
Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine
Section IV: Epilogue
Future Perspective.
Yuzhuo Wang, PhD
Director, Living Tumor Laboratory
Distinguished Scientist, BC Cancer Agency
Senior Scientist, Vancouver Prostate Centre
Professor, University of British Columbia
675 West 10th Avenue, Room 3.122
Vancouver, BC, Canada V5Z 1L3
Dong Lin, PhD, MD
Research Pathologist, Living Tumor Laboratory
<staff scientist,="" department="" of="" experimental="" therapeutics,="" bc="" cancer="" agency675="" west="" 10th="" avenue,="" room="" 3.220vancouver,="" bc,="" canada="" v5z="" 1l3
Peter W. Gout, PhD
Scientific Consultant, Living Tumor Laboratory
Honorary Associate Professor, Department of Urologic Sciences, University of British Columbia
Emeritus Senior Scientist, Department of Experimental Therapeutics, BC Cancer Agency
<675 West 10th Avenue, Room 5.108
Vancouver, BC, Canada V5Z 1L3
This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text.
Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.
Provides a comprehensive, state-of-the art review of PDX cancer models
Written by world-renowned experts in the field
Provides interactivity through extensive illustrations
