Non-Neuronal Mechanisms of Brain Damage and Repair After Stroke

This book provides a comprehensive overview of the latest research in the role of non-neuronal cells – astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials. Part 1. Microvascular integrity in stroke.- 1. Structural alterations to the endothelial tight junction complex during stroke.- 2. Role of pericytes in neurovascular unite and stroke.- 3. Glial support of blood-brain barrier integrity: Molecular targets for novel therapeutic strategies in stroke.- 4. Barrier mechanism in neonatal stroke.- 5. Angiogenesis: a realistic therapy for ischemic stroke.- Part 2. Glial cells in stroke.- 6. Astrocytes as a target for ischemic stroke.- 7. Microglia: a double-sided sword in stroke.- 8. Crosstalk between cerebral endothelium and oligodendrocyte after stroke.- Part 3. Peripheral immune cells in stroke.- 9. The peripheral immune response to stroke.- 10. The Role of spleen-derived immune cells in ischemic brain injury.- 11. Regulatory T cells in ischemic brain injury.- 12. B cells in stroke and preconditioning-induced protection against stroke.- 13. Mast cell as an early responder in ischemic brain injury.- 14. Roles of neutrophils in stroke.- 15. The function of cytokines in ischemic stroke.- Part 4. White matter injury and repair in stroke.- 16. Ischemic injury to white matter: an age-dependent process.- 17. Neurovascular repair after stroke.- 18. The role of non-neuronal Nrf2 pathway in ischemic stroke: damage control and potential tissue repair.- 19. Stem cell therapy for ischemic stroke. This book provides a comprehensive overview of the latest research in the role of non-neuronal cells – astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials. Discusses the roles of astrocytes, microglia, oligodendrocytes, endothelial cells, pericytes, and other immune cells