A new textbook of transplantation for infants and children is needed that is at least a first effort at achieving standard work in this field. Solid Organ Transplantation in Infants and Children provides a broad view of the current practice of solid organ transplantation in pediatric patients. It focuses on best practice and measureable outcomes whenever possible. It provides direct guidance for standard work in this broad and young field of clinical work. It portrays the regulatory environment in which this work occurs and the specific program requirements for each clinical program. Organized in two volumes, the first volume is devoted to the pediatric patient and their particular needs or concerns. This volume also contains information on the regulatory environment and pediatric program specific requirements. The second volume is devoted to the standard work in each solid organ transplanted. These volumes will be very useful for every practicing pediatric transplant program in the United States and Canada and much of the developed world. By reading these volumes, the reader will gain a firm understanding and practical knowledge of standard work in solid organ transplantation and the regulatory environment and requirements of programs to do that work. S olid organ transplantation in infants and children: Through the looking glass.- Key differences in recipient characteristics in infants and children.- The Pediatrician and the care of the infant or child before and after solid organ transplantation.- Solid organ transplantation in the pediatric patient: the regulatory environment and it’s requirements.- Evaluation and listing for transplant of the infant or child with end organ failure.- Maintenance of the infant or child with end organ failure.- Growth and development with end organ failure.- Anesthetic considerations for the child undergoing transplantation.- Intensive care of the child after solid organ transplantation.- Pathology of transplanted solid organs.- Immunologic responses of the child to short and long term immunosuppression.- Standard Immunosuppression.- Standard maintenance protocols: Medication, follow up visits, immunizations, sick child calls etc.- Immunosuppressive medication withdrawal.- Health related quality of life.- Late complications.- Progressive allograft injury and chronic rejection.- Nonadherence.- Retransplantation: challenges and strategies.- Transition to the adult care paradigm.- Growing up after a transplant: the child’s perspective.- Raising a child after a transplant: the parent’s perspective.- Continuous improvement in solid organ transplantation in infants and children.- The causes of kidney failure and timing of transplant.- The urine reservoir: evaluation and transplant strategies.- Technical aspects of kidney transplantation in the child.- Living donor kidney transplantation.- Salvage procedures for technical complications after kidney transplantation.- The causes of liver failure and timing of transplant.- Acute hepatic failure: Diagnosis, support and transplantation.- Technical aspects of liver transplantation.- Live donor liver transplantation: pediatric considerations.- Salvage procedures for technical complications after liver transplantation.- Causes of intestinal.- Technical aspects of intestinal transplantation.- Post transplant feeding regimens and monitoring paradigms.- Salvage procedures for technical complications after intestinal transplantation.- Living donor intestinal transplantation.- Causes of cardiac failure and timing of transplant.- Cardiac support devices and their use in infants and children in the overall strategy of cardiac transplantation.- Technical aspects of cardiac transplantation.- Salvage procedures for technical complications of cardiac transplantation.- Causes of lung failure in infants and children and timing of transplant.- Single or double lung transplantation: How to decide.- Combined heart-lung transplantation.- Technical aspects of lung and heart lung transplantation.- Salvage operations for technical complications after lung or heart-lung transplantation. Stephen P. Dunn, MD
Chair, AI Dupont Hospital for Children, Department of Surgery
Professor of Surgery, Jefferson Medical College, Wilmington, DE, USA.
Overview of the current practice of solid organ transplantation in pediactric patients
Supports practitioners with a focus on best practice and measureable outcomes
Shares the knowledge of experts in the field