This book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine. Vascular engineering is a multidisciplinary field integrating vascular biology, hemodynamics, biomechanics, tissue engineering, and medicine. Each chapter offers insights into the dynamics of the circulatory system and explains how the impact of related disease conditions — atherosclerosis, hypertension, myocardial ischemia, and cerebral infarction — has generated a focus on developing expertise to both maintain and treat the vascular system.
As a comprehensive book in this expanding area, Vascular Engineering serves as a valuable resource for clinicians as well as academics and professionals working in biophysics, biomedical engineering, and nano and microrheology. Graduate students in these subject areas will also find this volume insightful.
Chapter 1 Introduction
Chapter 2 Fundamentals of Vascular Bio-fluid and Solid Mechanics
Chapter 3 Fundamentals of Physiology and Biology of Vascular System
Chapter 4 Hemodynamics in Physio- and Pathological Vessels
Chapter 5 Cyclic Stretch-Induced Reorganization of Stress Fibers in Endothelial Cells
Chapter 6 Mechanical Characterization of Vascular Endothelial Cells Exposed to Fluid Shear Stress
Chapter 7 Tensile Properties of Smooth Muscle Cells, Elastin, and Collagen Fibers
Chapter 8 Mechanobiology of Endothelial Cells Related to the Formation of Arterial Disease
Chapter9 Mechanotransduction of Shear Stress by the Endothelium
Chapter 10 Mechanobiology of Endothelial Cells Related to the Pathogenesis of Arterial Disease
Chapter 11 Vascular Engineering of Blood Coagulation
Chapter 12 Vascular Engineering to Make Blood-Compatible Surface
Chapter 13 Vascular Engineering of Circulatory Assist Devices
Chapter 14 Innovations in Measuring Cellular Mechanics
Chapter 15 Innovation of Vascular Engineering by Mechano-medicine
Chapter 16 Integrated Vascular Engineering: Vascularization of Reconstructed Tissue
Chapter 17 Novel Technology to Assay the Multicellular Network: On-Chip Cellomics Technology
KazuoTanishita: Waseda University Research Organization for Nano & Life Innovation
Kimiko Yamamoto: Department of Biomedical Engineering, The University of Tokyo
This book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine. Vascular engineering is a multidisciplinary field integrating vascular biology, hemodynamics, biomechanics, tissue engineering, and medicine. Each chapter offers insights into the dynamics of the circulatory system and explains how the impact of related disease conditions — atherosclerosis, hypertension, myocardial ischemia, and cerebral infarction — has generated a focus on developing expertise to both maintain and treat the vascular system.
As a comprehensive book in this expanding area, Vascular Engineering serves as a valuable resource for clinicians as well as academics and professionals working in biophysics, biomedical engineering, and nano and microrheology. Graduate students in these subject areas will also find this volume insightful.
Examines the interdisciplinary field of vascular engineering from understanding the functionality of the circulatory system to the implications for innovative medical treatments
Covers cutting-edge research in molecular biology, biomedical engineering, and biophysics
Presents the development of new clinical modalities including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine
Includes step-by-step explanations of methodology and the related background for medical professionals, researchers, engineers, and graduate students
